After I've closed slic3r while it's being displayed on an external monitor connected to my laptop, it opens on that monitor afterwards and is therefore invisible if the monitor is not attached.
If I make sure it's on the laptop display when I shut it down it opens on the laptop display next time so no big deal but I thought I'd mention it as it puzzled me for a while and I had to wait until I could get the external monitor attached before I could use it again.
Tested on V1.2.5 and V1.2.6 on Windows 8.1 pro 64bit - high res screen on the laptop which does confuse some programs WRT font size but I don't think it's related to this.
Cheers,
Mark