printing issues

I am trying to use Slic3r and all the options seem to be kicking my ass......
All speeds are 100mm/s except 1st layer 50mm/s and small/external perimeters at 50%
Fill density 20% layer height .2mm

So here is a print

I have calibrated all axis and my extruder. Yet I still have raised rough corners and the top surface of the part has gaps.

Personally I never print that fast. Try 40-50mm/s on the perimeter and see if your just going too fast.

ok, so I slowed the print down to 50mm/s first layer, 75mm/s perimeter, small and external @50%, solid infill 90mm/s the rest 125mm/s.

Still have 1 bad corner

The corner that is messed up seems to be where the printer retract them extrudes before starting printing the next layer.

I have my retract at 4mm @ 60mm/s

Isn't there a checkbox option in Slic3r to randomize the starting point for each layer? If all else fails, at least it would distribute the ugliness around all four corners rather than butcher one completely.

You didn't mention what hotend, filament, or extruder you are using. With a long Bowden tube and geared extruder linked to a 0.4mm E3D hotend, I'm running 4.5mm retractions and 100mm/second retraction speed with 1.75mm PLA, and am still thinking that I need to retract a bit further on some parts. If you have a Bowden extruder setup, you might want to try upping the retraction speed if your stepper can do it.....

Running a Prusa i3 with a Wades geared extruder and a E3D hotend using 3mm ABS

I would lower the retract distance to somewhere between 1-2mm and bump up retract accleration if it's possible.

I have a wades extruder, running 1.5mm retract at 30mm/s with 5000mm/s2 accleration.

ok, here are 3 surface calibrations printed with the following settings:
; layer_height = 0.2
; perimeters = 3
; top_solid_layers = 5
; bottom_solid_layers = 5
; fill_density = 0.2
; perimeter_speed = 75
; infill_speed = 75
; travel_speed = 300
; nozzle_diameter = 0.35
; filament_diameter = 3.01
; extrusion_multiplier = 1
; perimeters extrusion width = 0.35mm
; infill extrusion width = 0.52mm
; solid infill extrusion width = 0.52mm
; top infill extrusion width = 0.52mm

I still see some issues with the first couple layers. I looks like the 1st layer is too think and the nozzle drags thru it leaving that blob on the outside lower left corner